Novel Role of Transient Receptor Potential Vanilloid 2 in the Regulation of Cardiac

نویسندگان

  • Jack Rubinstein
  • Valerie M. Lasko
  • Sheryl E. Koch
  • Vivek P. Singh
  • Vinicius Carreira
  • Nathan Robbins
  • Amit R. Patel
  • Min Jiang
  • Philip Bidwell
  • Evangelia G. Kranias
  • W. Keith
  • John N. Lorenz
چکیده

11 Running Head: TRPV2 channels in cardiac function 12 13 14 15 Corresponding author: 16 17 Jack Rubinstein, M.D 18 Department of Internal Medicine, 19 Division of Cardiovascular Diseases 20 University of Cincinnati 21 College of Medicine 22 231 Albert Sabin Way, ML0542 23 Cincinnati, OH 45267 24 25 Phone: 513-558-3062 26 Fax:513-558-4545 27 e-mail: [email protected] 28 29 30 Articles in PresS. Am J Physiol Heart Circ Physiol (December 6, 2013). doi:10.1152/ajpheart.00854.2013

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Capsazepine, a Transient Receptor Potential Vanilloid Type 1 (TRPV1) Antagonist, Attenuates Antinociceptive Effect of CB1 Receptor agonist, WIN55,212-2, in the Rat Nucleus Cuneiformis

Introduction: Nucleus cuneiformis (NCF), as part of descending pain inhibitory system, cooperates with periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) in supraspinal modulation of pain. Cannabinoids have analgesic effects in the PAG, RVM and NCF. The transient receptor potential vanilloid type 1(TRPV1) can be activated by anandamide and WIN55,212-2 as a cannabinoid receptor ago...

متن کامل

Morphine-induced analgesic tolerance is associated with alteration of protein kinase Cγ and transient receptor potential vanilloid type 1 genes expression in rat lumbosacral cord and midbrain

Introduction: Transient receptor potential vanilloid type 1 (TRPV1) and protein kinase Cγ (PKCγ) are involved in sensitization/desensitization to noxious stimuli. We aimed to examine the gene expression levels of TRPV1 and PKCγ in rat lumbosacral cord and midbrain on days 1, 4 and 8 of induction of morphine analgesic tolerance. Methods: Two groups of male Wistar rats received ...

متن کامل

Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains

Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown. Females are more commonly affected by fibromyalgia, exhibiting symptoms such as widespread mechanical pain, immune dysfunction, sleep disturbances, and poor quality of life. Electroacupuncture (EA) has been us...

متن کامل

Interaction Between the Cannabinoid and Vanilloid Systems on Anxiety in Male Rats

Introduction: Previous studies have shown that the cannabinoid system is involved in anxiety.In addition, transient receptor potential vanilloid type-1 (TRPV1) channels are new targets for the development of anxiolytics. The present study investigated the possible interaction between the cannabinoid and vanilloid systems on anxiety-like behavior in rats. Methods: Four different groups of male ...

متن کامل

Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance.

Transient receptor potential cation channels have been implicated in the regulation of cardiovascular function, but only recently has our laboratory described the vanilloid-2 subtype (TRPV2) in the cardiomyocyte, though its exact mechanism of action has not yet been established. This study tests the hypothesis that TRPV2 plays an important role in regulating myocyte contractility under physiolo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013